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Health Deep Dives15 min read

Water: the overlooked foundation of health and performance

How fluid balance works, why exercise changes the picture, and what urine and blood results can and cannot tell you about hydration.

Written by Dr Robert Stevens, MBChB MRCGP Dip.FIPT, Founder and Clinical Adviser to Praetor

The nutrient people forget

Nutrition discussions often begin with protein, fat and carbohydrate. Before long, the conversation becomes a debate about which dietary pattern is best. Water tends to receive less attention, despite being essential to every one of those approaches.

Water does not provide energy in the way the three main macronutrients do. It provides the environment in which much of our physiology takes place. We obtain it from drinks and food, and continually lose it through urine, sweat, breathing and the gut.

The body is constantly adjusting that balance. A reasonable intake on a cool rest day may be inadequate during prolonged exercise in the heat. Equally, forcing down large volumes because more seems healthier can create a different problem.

Hydration needs context.

Sources:[1][2]

What water does

Water is the main component of plasma, helping maintain the circulating volume that carries oxygen, nutrients, hormones and waste products around the body.

It is central to temperature regulation. Working muscle produces heat. Blood flow carries heat towards the skin, and sweat removes heat as it evaporates. Temperature, humidity, clothing and available body water all influence how effectively that system works.

Inside and outside cells, water provides the medium for chemical reactions and the distribution of dissolved substances. Sodium and Potassium contribute to fluid balance and the electrical gradients required for nerve and muscle function.

The kidneys filter the blood, recover needed water and solutes, and excrete waste. They work with thirst and hormonal signals to adjust excretion as circumstances change. Drinking a glass of water does not simply add a fixed amount to a tank and then pass straight through.

Water also contributes to digestive secretions and stool consistency. Normal fluid balance supports physical and cognitive function, but headache, fatigue and poor concentration have many possible causes. They should not automatically be explained as dehydration.

Sources:[2][3][5]

Why there is no single daily target

The NHS guide of six to eight cups or glasses of fluid daily is a population starting point. It includes drinks other than plain water, and food also provides moisture.

Requirements vary with body size and composition, diet, age, weather, altitude, clothing, exercise intensity and duration, sweat rate, heat acclimatisation and alcohol intake. Fever, vomiting and diarrhoea can change losses substantially. Pregnancy and breastfeeding can increase requirements too.

Medicines that affect urine output and conditions involving the heart, kidneys or endocrine system can change what is appropriate. A person with a prescribed fluid restriction should not replace that advice with a general internet target.

A fixed litre goal can therefore be too much for one person and too little for another. The day's circumstances and existing medical guidance matter more than reaching an arbitrary number.

Sources:[1][2][4][23]

Exercise changes fluid losses

Two people can complete the same session and lose very different amounts of sweat. Intensity, duration, heat, humidity, clothing, acclimatisation, body size and individual physiology all contribute.

Comparing body mass before and after a longer session can help estimate the scale of loss. Measurements need to be made under comparable conditions, with drinks and urine during the session accounted for.

The result is still an estimate. Food and fluid in the gut, wet clothing, scale error, and the fuel and water used or produced during exercise introduce uncertainty. One session also cannot determine requirements for every future session, especially when the weather or intensity changes.

The practical aim is to avoid deliberately starting underhydrated and to avoid gaining body mass by forcing down excess fluid during exercise. A prolonged event, demanding work in heat, previous heat illness or exercise-associated hyponatraemia may justify an individual plan with a sports dietitian or clinician.

Sources:[4][5][6]

Too little and too much

Dehydration broadly describes a shortfall in body water. Reduced circulating volume, sometimes termed hypovolaemia, is related but not identical; water and salt losses can occur in different proportions.

Thirst, dry mouth, headache, tiredness, dizziness, darker urine and reduced urine output may accompany dehydration. They are not specific enough to establish the diagnosis on their own. Illness, fever, gastrointestinal losses and heavy sweating can increase risk. Older adults are particularly vulnerable, although this article concerns adults generally.

Excessive intake can also be dangerous. If water is consumed faster than the body can excrete it, the sodium concentration in blood may fall. During or shortly after exercise, this may represent exercise-associated hyponatraemia.

It can occur with water or sports drinks. Adding some sodium to a drink does not cancel the risk created by excessive fluid intake relative to losses and impaired water excretion.

Early symptoms such as headache, nausea and lethargy can overlap with dehydration or heat illness. Confusion, seizures or reduced consciousness are emergency signs. Guessing whether someone needs more water or more salt is not an adequate response to serious symptoms.

Sources:[6][8][23][25]

Practical clues and their limits

Thirst is useful in ordinary daily life and many exercise settings. Its reliability can be affected by age, illness, medicines and whether drinks are readily available.

Pale yellow urine is a useful everyday prompt. Darker urine and passing less than usual can accompany dehydration, but first-morning urine is normally more concentrated. Foods, vitamins, medicines, exercise, alcohol and illness can alter colour or frequency. The association between urine colour and hydration is also less reliable in older adults.

Colourless urine is not a target. It may simply reflect recent high fluid intake.

Consider what has happened recently: heat exposure, travel, exercise, alcohol, fever, vomiting or diarrhoea. Where appropriate, repeated body-mass comparisons around exercise can add information, but should not become a rigid drinking prescription based on one workout.

If symptoms persist, the clues disagree or urine is red, brown or otherwise unusual, seek clinical advice. Blood in urine must not be dismissed as a hydration issue.

Sources:[1][5][7][22][23]

Water and electrolyte products

For everyday activity and many shorter or easier sessions, water with normal meals is generally adequate. Food provides Sodium, Potassium and other minerals. An electrolyte drink is not an automatic requirement for anyone who exercises.

A drink containing Sodium and carbohydrate may be useful when exercise is prolonged or demanding, sweat losses are high, the weather is hot, recovery time is limited or food is impractical. The formulation and amount depend on the person, event, diet and environment.

Sports drinks and oral rehydration solutions are not interchangeable. Vomiting and diarrhoea can produce losses of water and salts; a pharmacist can advise on an appropriate oral rehydration product where indicated.

Electrolytes are physiologically active substances. They are not a harmless insurance policy, particularly for someone with kidney, heart or liver disease, an endocrine condition or a fluid restriction. A clinically significant Sodium or Potassium abnormality requires diagnosis and supervised management, not a supplement chosen from the laboratory flag.

Sources:[1][5][6][23][26]

What kidney blood tests can show

A routine panel does not diagnose hydration. It may reveal a pattern that raises questions about fluid balance, but several different mechanisms can produce similar results.

Urea is produced during protein metabolism and cleared mainly by the kidneys. It can rise when kidney perfusion or circulating volume is reduced. Protein intake, gastrointestinal bleeding, kidney clearance and severe liver disease can also alter it. Urea alone cannot distinguish those explanations.

Creatinine reflects creatine metabolism, particularly in muscle. It is used in equations that estimate glomerular filtration rate, or eGFR. That estimate is not a direct measurement of filtration.

Muscle mass, recent meat intake, supplements, acute illness and kidney perfusion can affect interpretation. Creatine supplementation can modestly raise serum Creatinine without a corresponding fall in measured filtration. Recent hard exercise can add further changes through muscle metabolism and plasma-volume shifts.

Those possibilities are reasons to interpret a result carefully, not reasons to ignore an unexpected deterioration. Clinical history, medicines, previous results, examination and sometimes additional blood or urine tests may be needed.

Sources:[8][9][10][11][12][13]

Sodium and Potassium

Sodium and Potassium results are concentrations in a blood sample. They do not directly measure total body water or total electrolyte stores.

Sodium can change with the relationship between salt and water, kidney function and hormonal regulation. A normal Sodium result does not prove ideal hydration, and a low value is not automatically a reason to eat more salt or restrict fluid without advice.

Potassium can change with kidney disease, medicines and gastrointestinal losses, among other causes. Damage to blood cells during collection or handling can release Potassium and produce a falsely high result. The possibility of a collection problem needs proper assessment because genuinely abnormal Potassium can be important.

Do not use an isolated result to decide independently to drink more, drink less or take electrolytes. The same flag can have different causes and require very different responses.

Sources:[8][9][10][14][25]

Blood counts and plasma volume

When plasma volume falls, some measured concentrations can appear higher even if the total amount in the body has not increased. This is haemoconcentration. Expansion of plasma volume can produce the opposite effect, haemodilution.

Haemoglobin, Haematocrit and red blood cell count may therefore be affected by fluid shifts. Haematocrit is also influenced by posture, sampling, recent exercise, heat acclimatisation and the individual's baseline.

A raised red cell count has other possible causes, including smoking, altitude, lung or heart disease and bone marrow conditions. A high result should not automatically be attributed to dehydration. A normal result does not exclude fluid imbalance either.

There is no reliable hydration score hidden in a Full Blood Count. The concentration effects are real, but neither sufficiently uniform nor specific for that purpose.

Sources:[15][16][17]

Albumin and Bilirubin

Albumin is a major plasma protein. Concentration changes can influence its measured value, but inflammation, liver function, malabsorption and protein loss through the kidneys or intestines also matter. Low Albumin is not proof of overhydration, and high Albumin is not a stand-alone test for dehydration.

Bilirubin is produced from the breakdown of red blood cells and processed by the liver. It should not be treated as a hydration marker or assumed to normalise simply by drinking more water.

Gilbert syndrome is a specific exception worth understanding: dehydration can trigger an isolated unconjugated Bilirubin rise in some people with this benign inherited condition. Even then, a new or unusual result needs to fit the established clinical picture.

Other explanations for raised Bilirubin include haemolysis, liver disease and bile-flow obstruction. Yellowing of the skin or whites of the eyes requires urgent medical assessment rather than an assumption about hydration.

Sources:[18][19][20][21]

A realistic routine

Drink regularly, respond to thirst in context and remember that food and other drinks contribute. Plan access to fluid when heat, travel or longer activity will make that difficult. Avoid deliberate restriction and forced overdrinking.

For a blood test, follow the supplied preparation instructions. Drinking unusually large volumes to improve a result can change the sample rather than make it more representative.

Anyone with significant heart, kidney or liver disease, an endocrine disorder or a prescribed fluid limit needs individual advice. Pregnancy and medicines affecting fluid balance may also change what is appropriate.

Depending on the panel, Praetor tests may include Kidney Function, Full Blood Count, Albumin and Bilirubin. These results can contribute to assessment, but no panel diagnoses hydration or sets an individual fluid target.

Sources:[1][4][23][26]

When to seek help

Call 999 if someone is confused, has a seizure, collapses, loses consciousness, is difficult to wake, has difficulty breathing or has signs of heatstroke, including very hot skin with neurological symptoms. During or after exercise, these findings can have several causes. Do not assume that giving more water is the answer.

Seek urgent advice through NHS 111 for persistent dizziness on standing, markedly reduced urine output, rapid breathing or heartbeat, unusual drowsiness, repeated vomiting or inability to keep fluids down. Following prolonged exercise, new headache, nausea, weakness or swelling, particularly after drinking large amounts, also needs prompt assessment.

Symptoms, examination and the wider circumstances guide the response. A laboratory result cannot replace that assessment.

Sources:[6][23][24][25]

References

  1. Water, drinks and hydration (opens in a new window)

    NHS. Reviewed 17 May 2023. Accessed 2 August 2026.

    Supports: The 6 to 8 cups or glasses population guide, regular drinking, food and other drinks contributing fluid, and higher needs with pregnancy, breastfeeding, heat, activity or illness.

  2. Scientific Opinion on Dietary Reference Values for water (opens in a new window)

    EFSA Journal. Accessed 2 August 2026.

    Supports: Water as an essential nutrient, why nutrient requirements vary, and why dietary reference values are population benchmarks rather than individual prescriptions.

  3. Physiology, Osmoregulation and Excretion (opens in a new window)

    NCBI Bookshelf, StatPearls. Updated 1 May 2023. Accessed 2 August 2026.

    Supports: The roles of body water in biochemical reactions, nutrient transport, thermoregulation, cellular compartments and kidney-mediated osmoregulation.

  4. Beat the heat: staying safe in hot weather (opens in a new window)

    UK Health Security Agency and Centre for Climate and Health Security. Published 10 May 2023. Updated 21 July 2026. Accessed 2 August 2026.

    Supports: Heat as a changing hydration context, planning physical activity for cooler periods, drinking fluids and recognising heat-related illness risk.

  5. National Athletic Trainers' Association Position Statement: Fluid Replacement for the Physically Active (opens in a new window)

    Journal of Athletic Training. Accessed 2 August 2026.

    Supports: Individual variability in sweat loss, thermoregulation, exercise body-mass assessment, the risks of both underdrinking and overdrinking, and context-dependent use of carbohydrate or electrolytes.

  6. Statement of the Third International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015 (opens in a new window)

    Clinical Journal of Sport Medicine. Accessed 2 August 2026.

    Supports: Excessive fluid intake relative to losses as the main risk for exercise-associated hyponatraemia, the danger of weight gain during exercise, and why sports drinks do not prevent hyponatraemia when someone overdrinks.

  7. The Validity of Urine Color as a Hydration Biomarker within the General Adult Population and Athletes: A Systematic Review (opens in a new window)

    Journal of the American College of Nutrition. Published 24 April 2020. Accessed 2 August 2026.

    Supports: Urine colour as a practical but limited hydration indicator whose validity depends on the population, setting and method.

  8. A multidisciplinary consensus on dehydration: definitions, diagnostic methods and clinical implications (opens in a new window)

    Annals of Medicine. Accessed 2 August 2026.

    Supports: The distinction between dehydration and hypovolaemia, the complexity of hydration assessment, and the need to combine clinical and laboratory context rather than rely on one marker.

  9. Chronic kidney disease: assessment and management (opens in a new window)

    National Institute for Health and Care Excellence. Published 25 August 2021. Updated 24 November 2021. Accessed 2 August 2026.

    Supports: Limitations of creatinine-based eGFR in acute illness, pregnancy, altered muscle mass, malnutrition and protein-supplement use, plus the effect of recent meat intake.

  10. Intravenous fluid therapy in adults in hospital (opens in a new window)

    National Institute for Health and Care Excellence. Published 10 December 2013. Updated 5 May 2017. Accessed 2 August 2026.

    Supports: Clinical fluid assessment requiring symptoms, examination, fluid balance, weight and laboratory values including urea, creatinine and electrolytes rather than one blood result.

  11. Effect of creatine supplementation on kidney function: a systematic review and meta-analysis (opens in a new window)

    BMC Nephrology. Published 6 November 2025. Accessed 2 August 2026.

    Supports: Creatine supplementation being associated with a modest rise in serum creatinine without a significant change in glomerular filtration rate.

  12. Urea Test (opens in a new window)

    Lab Tests Online UK. Published 12 December 2025. Updated 18 February 2026. Accessed 2 August 2026.

    Supports: Protein breakdown and kidney clearance in urea physiology, with protein intake, gastrointestinal bleeding, severe liver disease and reduced kidney blood flow among the contexts that can alter a urea result.

  13. Creatinine (opens in a new window)

    Lab Tests Online UK. Published 12 December 2025. Updated 9 March 2026. Accessed 2 August 2026.

    Supports: Creatinine as a muscle-derived marker cleared by the kidneys, and the effects of muscle mass, large meat intake, creatine supplements, muscle injury and kidney perfusion on interpretation.

  14. Potassium Test (opens in a new window)

    Lab Tests Online UK. Published 12 December 2025. Updated 20 March 2026. Accessed 2 August 2026.

    Supports: Kidney, gastrointestinal and medicine-related causes of abnormal potassium, plus falsely raised results from blood-cell damage and collection or handling problems.

  15. Reviewing the current methods of assessing hydration in athletes (opens in a new window)

    Journal of the International Society of Sports Nutrition. Published 30 October 2020. Accessed 2 August 2026.

    Supports: Haematocrit as an indirect plasma-volume measure with limitations from posture, sampling, heat acclimatisation, exercise and individual baseline.

  16. Effect of dehydration on blood tests (opens in a new window)

    Practical Diabetes. Published 15 June 2017. Accessed 2 August 2026.

    Supports: How fluid-related concentration changes can affect haemoglobin, haematocrit, urea, creatinine, electrolytes and proteins without making any of them a stand-alone hydration test.

  17. Full blood count (FBC) (opens in a new window)

    Lab Tests Online UK. Published 12 December 2025. Updated 4 March 2026. Accessed 2 August 2026.

    Supports: Dehydration-related concentration as one possible cause of a high red blood cell count, alongside altitude, smoking, lung or heart conditions and bone marrow disease.

  18. Albumin (opens in a new window)

    Lab Tests Online UK. Published 12 December 2025. Updated 19 May 2026. Accessed 2 August 2026.

    Supports: Albumin in liver and kidney assessment, and low albumin in severe inflammation, infection, malabsorption and protein loss through the kidneys or intestines.

  19. Bilirubin (opens in a new window)

    Lab Tests Online UK. Published 12 December 2025. Updated 24 June 2026. Accessed 2 August 2026.

    Supports: Bilirubin as a product of red blood cell breakdown used in assessing liver function, with haemolysis, liver disease, bile-duct obstruction and Gilbert syndrome among the relevant contexts.

  20. Presentation: Patient with elevated unconjugated hyperbilirubin (opens in a new window)

    NHS England National Genomics Education Programme. Reviewed 28 February 2025. Accessed 2 August 2026.

    Supports: Dehydration as one possible trigger for an isolated unconjugated bilirubin rise in Gilbert syndrome and the need to consider haemolysis and liver context.

  21. Jaundice (opens in a new window)

    NHS. Reviewed 22 January 2024. Accessed 2 August 2026.

    Supports: Yellowing of the skin or whites of the eyes as jaundice that needs urgent medical assessment rather than attribution to hydration.

  22. Blood in urine (opens in a new window)

    NHS. Reviewed 19 May 2023. Accessed 2 August 2026.

    Supports: Red or brown urine as a possible sign of blood that needs clinical assessment rather than reassurance based on hydration alone.

  23. Dehydration (opens in a new window)

    NHS. Reviewed 1 May 2026. Accessed 2 August 2026.

    Supports: Symptoms and causes of dehydration, higher-risk groups, regular fluid intake, and the NHS 111 escalation signs used in this article.

  24. Heat exhaustion and heatstroke (opens in a new window)

    NHS. Reviewed 28 May 2026. Accessed 2 August 2026.

    Supports: Heatstroke as a medical emergency, including very hot skin, confusion, seizure, loss of consciousness, fast breathing and the need to call 999.

  25. Sodium (and urine) (opens in a new window)

    South Tees Hospitals NHS Foundation Trust. Updated 29 April 2024. Accessed 2 August 2026.

    Supports: Hyponatraemia as cellular overhydration, neurological symptoms including headache, confusion and seizures, and the range of fluid, kidney and endocrine contexts relevant to a sodium result.

  26. A guide to fluid restriction (opens in a new window)

    West Suffolk NHS Foundation Trust. Published 16 January 2025. Accessed 2 August 2026.

    Supports: Why heart, kidney, liver and endocrine conditions or hyponatraemia may require an individual fluid limit rather than general hydration advice.

Blood tests need context

Depending on the panel, Praetor tests can include kidney function, a full blood count, albumin and bilirubin. No panel diagnoses hydration.

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